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McInnes, Campbell
One or more keywords matched the following items that are connected to McInnes, Campbell
Item TypeName
Concept Cyclin-Dependent Kinase 8
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Cyclin-Dependent Kinase 2
Concept Cyclin-Dependent Kinase 4
Concept Cyclin-Dependent Kinase 9
Concept Cyclin-Dependent Kinase Inhibitor p27
Academic Article Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.
Academic Article 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
Academic Article Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
Academic Article Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Academic Article Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Academic Article Strategies for the design of potent and selective kinase inhibitors.
Academic Article Protein structures in virtual screening: a case study with CDK2.
Academic Article Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.
Academic Article Structure-based discovery and optimization of potential cancer therapeutics targeting the cell cycle.
Academic Article REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors.
Academic Article Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design.
Academic Article Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors.
Academic Article Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.
Academic Article Fragment based discovery of arginine isosteres through REPLACE: towards non-ATP competitive CDK inhibitors.
Academic Article Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.
Academic Article Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy.
Academic Article Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
Academic Article A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.
Search Criteria
  • Cyclin Dependent Kinase 6